About the project

Section 1 – Objectives

The project has four main objectives:

1. To build a white lupin pangenome graph serving as a reference for future genomic studies.

2. To identify a comprehensive set of genomic variants across wild and landrace accessions, minimizing reference bias.

3. To reconstruct the domestication history of Lupinus albus, determining when, where, and how many times domestication occurred.

4. To detect genomic loci most affected by artificial selection, providing valuable insights for crop improvement.
   
   

Section 2 – Background

Domestication reshaped the genomes of many plant species, including legumes. However, the evolutionary and genomic history of Lupinus albus remains largely unexplored.
Traditional genome sequencing methods, which rely on a single reference genome, are limited in capturing the full range of genetic variation. To overcome this, the project employs pangenome graph technology, integrating multiple genome assemblies to represent the species’ total diversity.

This approach allows researchers to uncover hidden genetic variation, structural variants, and gene presence/absence differences — key elements for understanding adaptation and selection during domestication.

Section 3 – Scientific relevance and impact

By combining genomic data from over 350 white lupin accessions, including wild forms and traditional landraces, this study will provide unprecedented resolution into the domestication process.
The outcomes will support breeders in improving Italian and European lupin varieties, enhancing adaptation to different environments, and promoting sustainable agriculture